2021–2025 Benchmarks: 105% Reserves, 20% SVT Pre-IPO, and Post-Liquidity Crashes

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Biotech and Life Sciences IPOs are the ultimate high-wire act — massive pre-IPO equity bets to win talent, followed by brutal post-IPO resets that attract relentless short sellers when trials stumble.

This targeted 14-page report distills the extreme outliers from Beta Existence’s 200+ IPO analysis, showing exactly how ownership bloat intersects with capital burn and liquidity cliffs in the most shorted Life Sciences names of 2021–2025.

Insider Revelations Include:

• Pre-IPO Extremes: Median 105.4% ownership reserved and 20.38% SVT — the highest across sectors — fueling talent wars in long-horizon R&D.
• Post-IPO Shock: Reserves crash to ~7%, SVT drops to 2.59%, and gross burn falls 89% as liquidity arrives… or clinical failures trigger shorts.
• Short-Seller Playbook: Negative cash-to-liabilities in loss-making firms, combined with 188% pre-IPO overhang, creates textbook downside setups.
• Defensive Benchmarks: Full percentile breakdowns to calibrate reserves, justify grants to institutional investors, and model dilution scenarios.

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